AVN is caused by interruption of the blood supply to the bone. If blood vessels are blocked with fat, become too thick or too small, or get too weak, they may not be able to provide the amount of blood necessary for the bone tissue to survive. Corticosteroids (such as prednisone and dexamethasone) given during cancer treatment , respiratory issues can affect the bone and blood vessels, resulting in AVN. As well as long term treatment of asthma with inhaled corticosteroids has been accompanied by concern about both systemic and topical side effects
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