The Graham, Leach, Bliley Act facilitated affiliation among banks, securities firms, and insurance companies. This allowed banks and insurance companies to speculate in riskier investments, these were typically "safe" places to store assets previously.
The Commodities Futures Modernization Act allowed all of the above institutions to speculate with clients assets in risky derivatives and futures contracts. These are the financial instruments which collapsed and brought our country into the deepest recession since 1933. This has affected not only the U.S. economy but, also, the world economy.
The Glass-Steagel Act separates the above mentioned institutions and regulates the Federal Reserve. ("in toto" means in it's enirety.)